Genetik Ufku

"Novel" genes are involved in the evolution of morphological diversity in the basal metazoan Hydra.

The most complete survey to date of bacterial diversity in the human gut shows extensive but temporary changes in the microbial community following ciprofloxacin treatment.

Members of the neurotrophin superfamily mediate critical roles in neuronal survival and targeting in the fruit fly Drosophila. Although this is an accepted role for neurotrophins in vertebrates, scant previous evidence has been able to demonstrate such a conserved role in invertebrates.

The assumption that the success of social insects rests on the increased efficiency of dividing tasks within the colony is challenged by evidence that specialists are not always better at their jobs.

Plant flower production is largely determined by the number of inflorescences, the branches produced on flower stems. Two genes identified in tomato reveal a new phase transition that may explain the mechanism of evolution of compound inflorescences in the Solanaceae family.

Nitric oxide is shown to control the pro- and anti-inflammatory functions of surfactant protein D by altering its quaternary structure via S-nitrosylation.

New neurons are born throughout life in the hippocampus. Cell-type-specific, single-gene ablation in newborn neurons reveals that the kinase cdk5 regulates growth of neuronal processes, identifying a key mechanism of neuronal integration within the adult brain.

An approach to induce specific tolerance--an important application for the treatment of autoimmune diseases and transplant rejections--uses polyclonal T cells transduced with an inducible form of Foxp3.

Transcription from within open reading frames in S. cerevisiae, which is normally repressed by many chromatin- and transcription-related factors, has the potential to be widespread and to express alternative genetic information.

Characterizing neuroectodermal enhancers located throughout the genomes of three Drosophila species reveals that each enhancer evolved functional adaptations that compensate for the evolutionary changes specific to each lineage.

A genome-wide screen in Saccharomyces cerevisiae identifies over 300 gene products that buffer environmental variation--dubbed phenotypic capacitors--and function as hubs in protein-protein and synthetic-lethal interaction networks.

Cell-autonomous inhibition of Drosophila para Na+ channel inactivation using a membrane-tethered spider toxin phase shifts circadian neuropeptide output from cellular oscillation, and the phase of morning anticipatory activity is determined by this phase-shifted neuropeptide output.